• br Material and methods br

  2025-01-24

  

  Material and methods Results Discussion In order to find new and improved ways of treating type 2 diabetes (T2D) and other related conditions it is vital that investigators gain a more in-depth understanding of the effects that anti-diabetic treatments, such as TZDs, have on molecules impli

• Previous studies have demonstrated that synaptic

  2025-01-24

  

  Previous studies have demonstrated that synaptic AMPARs can differ greatly in their mobility; some rapidly and constitutively cell adhesion molecules in and out of the synaptic membrane, while others remain somewhat stable in the synaptic membrane (Luscher et al., 1999, Luthi et al., 1999). We find

• The current study was designed to

  2025-01-24

  

  The current study was designed to investigate the effects of the 12/15-LOX inhibitor, LOXBlock-1 (LB1) in mice using a FeCl3-induced distal MCAO model, and to test its utility in conjunction with subsequent thrombolysis with tPA, which is to date the only FDA-approved drug for acute stroke treatment

• Ala a branched chain amino acid

  2025-01-24

  

  Ala, a branched chain amino acid, has been reported to play a functional role in intracellular pH regulation, and it typically accumulates in response to various stresses (Limami et al., 2008, Rocha et al., 2010). Our data demonstrated that increasing Cd concentrations at lower Cd doses resulted in

• The present study determined the effect of DCA

  2025-01-24

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that Cell viability measurement non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic

• br Materials and methods br Results br Discussion

  2025-01-24

  

  Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in Metronidazole death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a concentration-dep

• To assess relative metabolic activity and proliferation

  2025-01-24

  

  To assess relative metabolic activity and proliferation of In vitro transcribed EGFP mRNA attached to various substrates we used the MTT assay [29], [30]. In order to compare the metabolic activity of cells under the various conditions irrespective of the number or viability of the cells, we perfor

• We found that several anticancer drugs inhibit HT receptor

  2025-01-24

  

  We found that several anticancer drugs inhibit 5-HT3 PF-8380 current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used frequently

• To maintain ATP levels postmortem

  2025-01-23

  

  To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield Tipifarnib 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (P compared to the other treatments. Combined, lower ATP and greater IMP in syste

• Although several different membrane estrogen receptors have

  2025-01-23

  

  Although several different membrane estrogen receptors have been reported (Qiu et al., 2008; Revankar et al., 2005), a large percentage of membrane-initiated steroid hormone signaling appears to be performed by a subpopulation of the same receptors that act in the nucleus. Specifically, estrogen rec

• In this review we will present the traditional and

  2025-01-23

  

  In this review, we will present the traditional and actual strategies to study orphan receptors and identify their ligands. An extensive description of the orphan GPCR field has been published in 2013 by Davenport et al. [22]. Therefore, we will focus on the deorphanizations that were reported since

• PFK-015 br Conflict of interest br Acknowledgements br Intro

  2025-01-23

  

  Conflict of interest Acknowledgements Introduction The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling system that regulates diverse cellular functions, such as proliferation, differentiation, and apoptosis [1]. Apoptosis signal-regulating kinase 1 (A

• In conclusion the partial sequencing and characterization of

  2025-01-23

  

  In conclusion, the partial sequencing and characterization of R. quelen cyp19a1b provides essential information about this gene and its presence in peripheral tissues outside of the central nervous system in a teleost. Furthermore, we covered sex differences in the effects of E2 on the cyp19a1b gene

• br ROS in AiP and regeneration Tissue wounding

  2025-01-23

  

  ROS in AiP and regeneration Tissue wounding and inflammation are associated with production of ROS, and recent studies show that generation of ROS, especially during the initial stages of wounding and regeneration are essential for an efficient wound healing response. ROS, in particular H2O2 func

• br Metabolic effects of apelin in

  2025-01-23

  

  Metabolic effects of apelin in obesity and type 2 diabetes Mice fed a high fat diet (HFD) for several weeks become obese, hyperglycemic, hyperinsulinemic and insulin resistant. Acute apelin treatment by intravenous injection or by infusion during a hyperinsulinemic–euglycemic clamp in obese and i

14795 records 18/987 page Previous Next First page 上5页 1617181920 下5页 Last page